Introduction: Endometrial cancer (EC) is the most common gynecological cancer in developed countries. Histological grade (G) and myometrial invasion (MI) are important risk factors, and together with the histological type and other postoperative data establish the risk of lymph node involvement and guide the adjuvant treatments. The objective of this study was to assess the validity of a preoperative stratification model that combines preoperative histological grade and MI as identified by magnetic resonance imaging (MRI) to select candidates for lymph node staging and optimize surgical planning for our patients. Material and methods: It´s an observational retrospective cohort study including 294 patients diagnosed with EC at Donostia University Hospital from January 2012 to December 2017. Preoperative endometrial biopsy, including histological type and grade, preoperative MRI was compared with the definitive histological diagnosis. Sensitivity (Sn), specificity (Sp), positive predictive value (PPV) and negative predictive value (NPV) of the MRI-based diagnosis were calculated. Results: After inclusion and exclusion criteria 242 cases of type I or II EC were analyzed. Our model was found to have a Se of 91.4% (95% CI 83.2-95.8) and a Sp of 90.7% (95% CI 85.2-94.3). Percentage of down staging was 6.2% (15 unnecessary lymphadenectomies) and the upstaging rate was 2.9%. The NPV of the model was very high (95.4%, 95% CI 90.9-97.8). The diagnostic odds ratio for our model was 147.95 (95% CI 52.9-410.5), with a diagnostic accuracy of 91.7% (95% 87.6-94.6). Conclusions: A preoperative strategy that includes the determination of the tumor grade based on an endometrial biopsy and an assessment of MI by MRI is of great help in pre-surgical planning for endometrial cancer surgery, allowing an extra peritoneal approach and optimizing the use of physical and human resources. MRI presents excellent discriminatory power in the detection of MI in EC, with no significant variation by pathological subtype.

Background: Cervical cancer occurs when the cells of the cervix grow abnormally and invade other tissues and organs of the body. Aim: study the impact of an educational program on knowledge of women with cervical cancer Methods; Design: A quasi-experimental design. Setting: out-patient clinic in the oncology unit at Beni-Suef University Hospital. Subjects: ? purposive sample of 70 women. Tools: A structured interviewing questionnaire sheet, ? scoring system for womens knowledge ?bout cervical cancer, and supportive educational booklet. Results: The results of the study revealed improving in womens knowledge regarding cervical cancer post-program compared to pre-one. Conclusion: The teaching program was very effective in womens knowledge improvement. Recommendations: Womens counseling activities for women regarding cervical cancer need to be popularized and facilities and decision-making aids are made available to those who need them.

Meigs’ syndrome is a rare condition characterized by the presence of a benign fibroma of the ovary, ascites and pleural effusion. Other benign cysts of the ovary (such as struma ovarii, mucinous cystadenoma, serous cystadenoma and teratomas), leiomyoma of the uterus, and secondary metastatic tumours to ovary if associated with hydro thorax and ascites are referred to as ‘Pseudo-Meigs” syndrome. It very uncommon and diagnosis is made difficult by symptoms that usually mimic disseminated malignancy or tuberculosis. The gold standard treatment is laparotomy and, by definition of the syndrome, after tumor removal, the symptoms resolves and the patients become asymptomatic. We presented an 18 years old girl with giant ovarian serous cystadenoma with associated pseudo-meigs syndrome, successfully managed in a low resources setting.

Prenatal invasive diagnostic and therapeutic procedures have drastically reduced during COVID-19 pandemic. Unlike routine prenatal care, these are time bound and highly skilled procedures available at specialized centres. This adds to the limited accessibility for at-risk women. Major concerns including procedure related risk, exposure of health care personnel and vertical transmission of COVID-19. At newly developing tertiary centre, we had done 36 fetal procedures during pandemic including 25 amniocentesis, three chorion villus sampling and eight intrauterine transfusions. It is advisable to perform life-saving fetal interventions irrespective of COVID-19 status taking full precautions and proper counselling of women.

The human placenta once was thrown after the delivery, found to be a very useful organ though it has very short life. With more and new research the old concept about placenta has changed. Now it is well established that health of growing embryo depends on the health of the placenta. To begin with immunology of neonate also depends on transplacental transport. It is well established that the health of the growing embryo depends on the health of the transplacental transport. Normally, IgG can be transported through placenta however, in Covid-19 infected pregnant woman even IgM, which is much bigger molecule than IgG, can also be transported and are found in the embryo.